references
below are the peer-reviewed studies, human trials, clinical research, and
scientific reviews that informed our blend ratios and dosing.
lion's mane
hericenones → cognitive function
shiitake
lentinan → immune foundation
reishi
triterpenes → stress adaptation
turkey tail
PSK/PSP → immune activation
cordyceps
cordycepin → cellular energy
more potent than mushroom "coffee"
pfunct. per dropper
extractions (alcohol & water)
filler ingredients (just mushrooms)
most recent (& promising) results
LION’S MANE:
- Saitsu, Y., et al. (2023). Improvement of cognitive functions by oral intake of Hericium erinaceus. Nutrients, 15(20), 4300.
- Mori, K., et al. (2009). Improving effects of the mushroom Yamabushitake on mild cognitive impairment. Phytotherapy Research, 23(3), 367-372.
- Vigna, L., et al. (2019). Hericium erinaceus improves mood and sleep disorders in overweight or obese patients. Nutrients, 11(9), 2191.
REISHI:
- Zhao, H., et al. (2012). Spore powder of Ganoderma lucidum improves cancer-related fatigue. Evidence-Based Complementary and Alternative Medicine, 2012.
- Gao, Y., et al. (2003). Effects of Ganoderma lucidum (Reishi) on immune functions in advanced-stage cancer patients. Immunological Investigations, 32(3), 201-215.
- Chu, T. T., et al. (2016). Triterpenoids and polysaccharides from Ganoderma lucidum: Pharmacological effects and clinical applications. Pharmacological Research, 113, 373-388.
TURKEY TAIL:
- Torkelson, C. J., et al. (2012). Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncology, 2012.
- Oba, K., et al. (2009). Individual patient data meta-analysis of lentinan for unresectable/recurrent gastric cancer. Cancer Immunology, Immunotherapy, 58(11), 1843-1851.
- Pallav, K., et al. (2014). Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on gut microbiome. Global Advances in Health and Medicine, 3(3), 7-15.
CORDYCEPS:
- Yi, X., et al. (2016). Effects of Cordyceps militaris supplementation on exercise performance in healthy older adults. Journal of Dietary Supplements, 13(3), 276-287.
- Hirsch, K. R., et al. (2017). Cordyceps militaris improves tolerance to high-intensity exercise. Journal of Dietary Supplements, 14(1), 42-53.
- Zhu, J. S., et al. (2016). The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps. Chinese Medicine, 11, 7.
SHIITAKE:
- Dai, X., et al. (2015). Consuming Lentinula edodes (shiitake) mushrooms daily improves human immunity. Journal of the American College of Nutrition, 34(6), 478-487.
- Ina, K., et al. (2013). The use of lentinan for treating gastric cancer. Anti-Cancer Agents in Medicinal Chemistry, 13(5), 681-688.
- Guillamón, E., et al. (2011). Edible mushrooms: Role in the prevention of cardiovascular diseases. International Journal of Medicinal Mushrooms, 13(4), 333-345.
- Cheah, I.K., & Halliwell, B. (2012). Ergothioneine; antioxidant potential, physiological function and role in disease. Biochimica et Biophysica Acta, 1822(5), 784-793.
- Ames, B.N. (2018). Prolonging healthy aging: Longevity vitamins and proteins. Proceedings of the National Academy of Sciences, 115(43), 10836-10844.
- Kalaras, M.D., et al. (2017). Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Food Chemistry, 233, 429-433.
disclaimer – *these statements have not been evaluated by the Food and Drug Administration. Statements made on this site are not intended to diagnose, treat, cure, or prevent any disease
| Brand | Cost/Day (Therapeutic) | Servings Needed | Transparency | Source | Made in USA |
|---|---|---|---|---|---|
| pfunct. | $1.33 | 1 dropper | ✓ Exact mg listed | ✓ Spore-to-bottle NC | ✓ |
| Four Sigmatic | $8/day | 6 cups | ✗ Vague (500mg) | ✗ Sourced extracts | ✗ |
| RYZE | $12/day | 9 cups | ✗ 2000mg “blend” | ✗ Sourced extracts | ✗ |
| Host Defense | $4-6/day | 4-6 capsules | ✗ No beta-glucan % | ✗ Mycelium-on-grain | ✓ |
| Real Mushrooms | $2.50-4/day | 2-3 servings | ✓ Beta-glucans listed | ✓ Fruiting body | ✗ |
| Laird Superfood | $2-5/day | Unknown | ✗ No mg listed | ✗ Not disclosed | ✗ |